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New substance against brain fatigue and narcolepsy

The substance OSU6162 was developed by Nobel laureate Arvid Carlsson. According to clinical trials which were initiated in 2010, OSU6162 seems to alleviate dramatically the symptoms of brain fatigue after stroke. Extended trials have shown continued good results.

Even in narcolepsy, OSU6162 appears to have promising effects, according to an initial study in six patients. Narcolepsy is a disease that has afflicted many people in Europe after vaccination with Pandemrix against swine flu in 2009. Characteristic symptoms in narcolepsy are sudden sleep attacks, and cataplexy, that is sudden episodes of muscle weakness.

OSU6162 affects dopamine, a neurotransmitter which plays an important role in all of the brain functions. This substance exerts its action by stabilizing the function of dopamine, resulting also in at most mild side effects.

On the basis of his knowledge of OSU6162 and its way of action, Arvid Carlsson predicts that OSU6162 will be useful in, among other conditions, ADHD and dementia as well.

In a podcast from the Sahlgrenska Academy, University of Gothenburg, Arvid Carlsson is interviewed about his molecule and its effects.

Acta Neuropsychiatrica, Volume 24, Issue 5, Pages 266-274 2012

More publications by Arvid Carlsson:



Video of Arvid Carlsson´s research

In this interview, Arvid Carlsson, among other things, tells the exciting story of his discovery that dopamine is a neurotransmitter in the brain. We are given a quick review of Arvid Carlsson´s research and of the history of psychopharmacology. The interview took place at a "Molecular Frontiers Symposium" in Gothenburg in May 2015. Elias Eriksson, professor of psychopharmacology at the University of Gothenburg, made the interview.

The picture of the research of stem cells and regeneration of nerve cells is biased in the media

In their columns, Arvid and Lena write about current issues in brain research and psychiatry. Their latest columns are about research results which question the importance of the regeneration of nerve cells in the brain. Lena summarizes some interesting studies and Arvid comments the results.

Nobel Prize winner Arvid Carlsson has written the book Messengers of the Brain together with his daughter, Lena Carlsson.

For ordering:

If you wish to comment on the columns, please send an email to this website.


Usually, negative results of the research of stem cells and regeneration of nerve cells are not paid attention to. Many people believe for instance that new nerve cells can replace dead nerve cells in the adult human brain. This has however not yet been proven.


No new nerve cells are needed in learning, and depression is not caused by a reduction of the regeneration of nerve cells, according to studies.



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Updated in march 2016

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